Functional Sub-states by High-pressure Macromolecular Crystallography.

Abstract : At the molecular level, high-pressure perturbation is of particular interest for biological studies as it allows trapping conformational substates. Moreover, within the context of high-pressure adaptation of deep-sea organisms, it allows to decipher the molecular determinants of piezophily. To provide an accurate description of structural changes produced by pressure in a macromolecular system, developments have been made to adapt macromolecular crystallography to high-pressure studies. The present chapter is an overview of results obtained so far using high-pressure macromolecular techniques, from nucleic acids to virus capsid through monomeric as well as multimeric proteins.
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Article dans une revue
Sub-cellular biochemistry, 2015, 72, pp.215-35
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http://hal.univ-grenoble-alpes.fr/hal-01199273
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Soumis le : mardi 15 septembre 2015 - 11:10:45
Dernière modification le : mardi 24 avril 2018 - 01:39:47

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  • HAL Id : hal-01199273, version 1
  • PUBMED : 26174384

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Anne-Claire Dhaussy, Eric Girard. Functional Sub-states by High-pressure Macromolecular Crystallography.. Sub-cellular biochemistry, 2015, 72, pp.215-35. 〈hal-01199273〉

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