Structural analysis of a feline norovirus protruding domain.

Abstract : Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35Å resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain α-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.
Type de document :
Article dans une revue
Virology, Elsevier, 2015, 474, pp.181-5
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Contributeur : Frank Thomas <>
Soumis le : lundi 18 mai 2015 - 10:16:25
Dernière modification le : lundi 11 février 2019 - 16:51:12


  • HAL Id : hal-01152526, version 1
  • PUBMED : 25463616



Bishal K Singh, Sebastian Glatt, Jean-Luc Ferrer, Anna D Koromyslova, Mila M Leuthold, et al.. Structural analysis of a feline norovirus protruding domain.. Virology, Elsevier, 2015, 474, pp.181-5. 〈hal-01152526〉



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