Structural biology turned on its head.

Abstract : NMR spectroscopy and ITC have recently been combined to demonstrate how phosphorylation of the intrinsically disordered eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) induces folding into a stable three-dimensional structure. The classical structure-function paradigm is inverted, with phosphorylation-induced folding inhibiting binding to the eukaryotic translation initiation factor 4E (eIF4E) and thereby contributing to regulation of the interaction.
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ChemBioChem, Wiley-VCH Verlag, 2015, 16 (7), pp.1033-4. 〈10.1002/cbic.201500101〉
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Soumis le : mardi 12 mai 2015 - 10:44:11
Dernière modification le : lundi 19 février 2018 - 14:34:03

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Guillaume Bouvignies, Martin Blackledge. Structural biology turned on its head.. ChemBioChem, Wiley-VCH Verlag, 2015, 16 (7), pp.1033-4. 〈10.1002/cbic.201500101〉. 〈hal-01150896〉

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