Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.

Abstract : DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
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Article dans une revue
Chemical Communications, Royal Society of Chemistry, 2015, 51 (18), pp.3816-9
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http://hal.univ-grenoble-alpes.fr/hal-01149485
Contributeur : Frank Thomas <>
Soumis le : jeudi 7 mai 2015 - 10:53:25
Dernière modification le : lundi 19 février 2018 - 14:34:03

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  • HAL Id : hal-01149485, version 1
  • PUBMED : 25648900

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Stefania Ordanini, Norbert Varga, Vanessa Porkolab, Michel Thépaut, Laura Belvisi, et al.. Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.. Chemical Communications, Royal Society of Chemistry, 2015, 51 (18), pp.3816-9. 〈hal-01149485〉

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