Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.

Abstract : Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid.
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Article dans une revue
Antiviral Research, Elsevier Masson, 2013, 101, pp.57-61
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http://hal.univ-grenoble-alpes.fr/hal-01132369
Contributeur : Frank Thomas <>
Soumis le : mardi 17 mars 2015 - 09:58:04
Dernière modification le : samedi 7 avril 2018 - 14:40:02

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  • HAL Id : hal-01132369, version 1
  • PUBMED : 24184983

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R Germi, C Mariette, S Alain, J Lupo, A Thiebaut, et al.. Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.. Antiviral Research, Elsevier Masson, 2013, 101, pp.57-61. 〈hal-01132369〉

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