Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus. - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Antiviral Research Année : 2014

Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.

Résumé

Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid.
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Dates et versions

hal-01132369 , version 1 (17-03-2015)

Identifiants

  • HAL Id : hal-01132369 , version 1
  • PUBMED : 24184983

Citer

Raphaëlle Germi, C Mariette, S Alain, Julien Lupo, A Thiebaut, et al.. Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.. Antiviral Research, 2014, 101, pp.57-61. ⟨hal-01132369⟩
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