Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.

Abstract : Type III secretion systems (T3SS) are macromolecular complexes that translocate a wide number of effector proteins into eukaryotic host cells. Once within the cytoplasm, many T3SS effectors mimic the structure and/or function of eukaryotic proteins in order to manipulate signaling cascades, and thus play pivotal roles in colonization, invasion, survival and virulence. Structural biology techniques have played key roles in the unraveling of bacterial strategies employed for mimicry and targeting. This review provides an overall view of our current understanding of structure and function of T3SS effectors, as well as of the different classes of eukaryotic proteins that are targeted and the consequences for the infected cell.
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Article dans une revue
Research in Microbiology, Elsevier, 2013, 164 (6), pp.605-19
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Soumis le : vendredi 13 mars 2015 - 09:05:49
Dernière modification le : lundi 19 février 2018 - 14:34:03

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  • HAL Id : hal-01131149, version 1
  • PUBMED : 23541478

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Tommaso Tosi, Alexander Pflug, Karen F Discola, David Neves, Andréa Dessen. Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.. Research in Microbiology, Elsevier, 2013, 164 (6), pp.605-19. 〈hal-01131149〉

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