Intrinsically disordered proteins implicated in paramyxoviral replication machinery.

Abstract : The development of mechanistic insight into the molecular basis of how intrinsically disordered proteins function is a key challenge for contemporary molecular biology. Intrinsic protein disorder is abundant in the replication machinery of paramyxoviruses. In order to study this kind of protein, new methods are required that specifically take account of the highly dynamic nature of the chain, and describe this disorder in quantitative terms. Here we review recent studies of conformational disorder in paramyxoviral phosphoproteins and nucleoproteins using solution-based approaches such as nuclear magnetic resonance.
Type de document :
Article dans une revue
Current Opinion in Virology, Elsevier, 2014, 5, pp.72-81
Liste complète des métadonnées

http://hal.univ-grenoble-alpes.fr/hal-01131145
Contributeur : Frank Thomas <>
Soumis le : vendredi 13 mars 2015 - 08:56:05
Dernière modification le : lundi 19 février 2018 - 14:34:03

Identifiants

  • HAL Id : hal-01131145, version 1
  • PUBMED : 24631901

Collections

Citation

Guillaume Communie, Rob W H Ruigrok, Malene Ringkjøbing Jensen, Martin Blackledge. Intrinsically disordered proteins implicated in paramyxoviral replication machinery.. Current Opinion in Virology, Elsevier, 2014, 5, pp.72-81. 〈hal-01131145〉

Partager

Métriques

Consultations de la notice

91