Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1.

Abstract : Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through an unknown mechanism. Here, we report that reconstituted CENP-A nucleosomes are amenable to ATP-dependent SWI/SNF-mediated remodelling but are less permissive to acetylation and acetylation-dependent in vitro chromatin transcription. Remarkably, the transcriptional repression of the CENP-A chromatinized template could be relieved by the ectopic addition of histone chaperone, nucleophosmin.
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Article dans une revue
Journal of Biochemistry, Oxford University Press (OUP), 2014, 156 (4), pp.221-7
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http://hal.univ-grenoble-alpes.fr/hal-01130583
Contributeur : Frank Thomas <>
Soumis le : jeudi 12 mars 2015 - 08:45:58
Dernière modification le : lundi 19 février 2018 - 14:34:03

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  • HAL Id : hal-01130583, version 1
  • PUBMED : 24839294

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Jayasha Shandilya, Parijat Senapati, Fabienne Hans, Hervé Menoni, Philippe Bouvet, et al.. Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1.. Journal of Biochemistry, Oxford University Press (OUP), 2014, 156 (4), pp.221-7. 〈hal-01130583〉

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