Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1. - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Journal of Biochemistry Année : 2014

Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1.

Résumé

Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through an unknown mechanism. Here, we report that reconstituted CENP-A nucleosomes are amenable to ATP-dependent SWI/SNF-mediated remodelling but are less permissive to acetylation and acetylation-dependent in vitro chromatin transcription. Remarkably, the transcriptional repression of the CENP-A chromatinized template could be relieved by the ectopic addition of histone chaperone, nucleophosmin.
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Dates et versions

hal-01130583 , version 1 (12-03-2015)

Identifiants

  • HAL Id : hal-01130583 , version 1
  • PUBMED : 24839294

Citer

Jayasha Shandilya, Parijat Senapati, Fabienne Hans, Hervé Menoni, Philippe Bouvet, et al.. Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1.. Journal of Biochemistry, 2014, 156 (4), pp.221-7. ⟨hal-01130583⟩
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