Novel Mn-SOD Mimetics Offer Superior Protection Against Oxidative Damages in Hek293 Kidney Cells

Abstract : A series of ternary Mn (II) complexes have been synthesized employing combination of thiosemicarbazones as primary ligand and bipyridyl/aminoethanethiol as ancillary ligands and structurally characterized. The compounds were examined for their protective effects in Xanthine–Xanthine oxidase-induced oxidative stress in HEK-293 kidney cells using MTT assay, confocal imaging and Western blots. All compounds offer protection against the oxidative stress generated by Xanthine–Xanthine oxidase system, while compounds having aminoethanethiol as ancillary ligands especially exhibit potent effects even at nanomolar concentrations. These compounds seem to operate mechanistically through quenching of ROS and enhancing Mn-SOD expression in mitochondria.
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Journal of Pharmaceutical Sciences and Pharmacology, 2014, 1 (2), pp.1-8. 〈10.1166/jpsp.2014.1011〉
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http://hal.univ-grenoble-alpes.fr/hal-01075943
Contributeur : Vincent Niviere <>
Soumis le : lundi 20 octobre 2014 - 16:41:57
Dernière modification le : jeudi 28 juin 2018 - 09:51:14

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Alok Vyas, Vasundhara Kain, Zahra Afrasiabi, Sandhya Sitasawad, Madhukar Khetmalas, et al.. Novel Mn-SOD Mimetics Offer Superior Protection Against Oxidative Damages in Hek293 Kidney Cells. Journal of Pharmaceutical Sciences and Pharmacology, 2014, 1 (2), pp.1-8. 〈10.1166/jpsp.2014.1011〉. 〈hal-01075943〉

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